Article

Structure and mechanism of the BRCA2 tumour suppressor

2015-01-01

Abstract excerpt

Mutations in the human BRCA2 gene are a leading cause of susceptibility to breast, ovarian and prostate cancers. Its protein equivalent BRCA2, is the key mediator in repair of double-stranded DNA breaks and interstrand crosslinks - the most dangerous forms of DNA damage, via RAD51 effected homologous recombination. Thereby, preferably the sister chromatid, or homologous chromosome is utilised to drive the repair....

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Literature Corpus work: 18888cbd-fc08-51d6-9dd3-50ebfcc92389
DOI: 10.25560/25538

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