Article
Mutation rate and predicted phenotypic target sizes in ethylnitrosourea-treated mice.
Genetics - 1 Oct 2004
Concepcion Dorothy, Seburn Kevin L, Wen Gen, Frankel Wayne N, Hamilton Bruce A
Abstract excerpt
Chemical mutagenesis of the mouse is ongoing in several centers around the world, with varying estimates of mutation rate and number of sites mutable to phenotype. To address these questions, we sequenced approximately 9.6 Mb of DNA from G1 progeny of ethylnitrosourea-treated mice in a large, broad-spectrum screen. We identified 10 mutations at eight unique sites, including six nonsynonymous coding substitutions....
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