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Article

Association of DNA methylation, polymorphism and mRNA level of ALAS1 with antituberculosis drug-induced liver injury.

Pharmacogenomics - 1 Jan 2024

Hao Zhuolu, Han Bing, Zhou Xinyue, Jian Hongkai, He Xiaomin, Lu Lihuan, Zhang Meiling, Pan Hongqiu, Yi Honggang, Tang Shaowen

Abstract excerpt

Aim: To investigate the association of DNA methylation, genetic polymorphisms and mRNA level of aminolevulinate synthase 1 (ALAS1) with antituberculosis drug-induced liver injury (AT-DILI) risk.Methods: Based on a 1:1 matched case-control study with 182 cases and 182 controls, one CpG island and three single nucleotide polymorphisms (SNPs) were detected. ALAS1 mRNA level was detected in 34 samples.Results:...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39263813
DOI: 10.1080/14622416.2024.2392480
PMCID: PMC11492648

Genes

ALAS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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