Article
Involvement of cytochrome P450 1A1 and glutathione S-transferase P1 polymorphisms and promoter hypermethylation in the progression of anti-tuberculosis drug-induced liver injury: a case-control study.
PloS one - 1 Jan 2015
He Lei, Gao Li, Shi Zhe, Li Yuhong, Zhu Lingyan, Li Shiming, Zhang Peng, Zheng Guoying, Ren Qi, Li Yun, Hu Bo, Feng Fumin
Abstract excerpt
BACKGROUND: Anti-tuberculosis (anti-TB) drug-induced liver injury (ADLI) is one of the most common adverse effects associated with TB treatment. Cytochrome P450 (CYP) 1A1 and glutathione S-transferase (GST) P1 are important phase I/II metabolizing enzymes involved in drug metabolism and detoxification. Genetic polymorphism and CpG island methylation have been reported as factors influencing the expression of...
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