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Article

Association of Gene Polymorphisms and Serum Levels of ALAS1 with the Risk of Anti-Tuberculosis Drug-Induced Liver Injury.

Journal of clinical pharmacology - 1 Feb 2025

Han Bing, He Yiwen, Zhu Min, Zhang Meiling, Lu Lihuan, Xu Xiaoyan, He Xiaomin, Yi Honggang, Tang Shaowen

Abstract excerpt

The accumulation of protoporphyrin IX in the liver caused by isoniazid and rifampicin through the disorder of heme biosynthesis was considered an important mechanism of anti-tuberculosis drug-induced liver injury (ATLI). Alanine synthase 1 (ALAS1) is a rate-limiting enzyme in the process of heme synthesis. This study aimed to investigate the association between ALAS1 gene polymorphism, serum ALAS1 level, and the...

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Source

Identifiers

PMID: 39297668
DOI: 10.1002/jcph.6137

Genes

ALAS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Association of Gene Polymorphisms and Serum Levels of ALAS1 with the Risk of Anti-Tuberculosis Drug-Induced Liver Injury.PMID 39297668Read ↗

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