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The association of CpG island DNA methylation in the promoter region, genetic polymorphism of ALAS1 with anti-tuberculosis drug-induced liver injury

2023-07-31

Abstract excerpt

<title>Abstract</title> <p>Anti-tuberculosis drug-induced liver injury (AT-DILI) may be related to the accumulation of hepatotoxin protoporphyrin IX, while aminolevulinate synthase 1 (ALAS1) is the key rate-limiting enzyme. The study aimed to investigate the association of CpG island methylation, genetic polymorphism of ALAS1 with the risk of AT-DILI. Based on 1:1 matched case-control study with 150 AT-DILI cases...

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Literature Corpus work
d3af71c0-6cb7-50f4-92d7-c2eb772547f9
DOI
10.21203/rs.3.rs-3201969/v1
Open publication

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The association of CpG island DNA methylation in the promoter region, genetic polymorphism of ALAS1 with anti-tuberculosis drug-induced liver injuryDOI 10.21203/rs.3.rs-3201969/v1
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