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Article

No interaction between genetic variants and DNA methylation of the ferrochelatase gene in relation to antituberculosis drug-induced liver injury.

Pharmacogenetics and genomics - 1 Mar 2026

Wang Fei, Zhang Meiling, Wu Yu, Cheng Jingru, Chen Ruina, Pan Hongqiu, Lu Lihuan, He Xiaomin, Yi Honggang, Tang Shaowen

Abstract excerpt

OBJECTIVE: The pathogenic mechanisms of antituberculosis drug-induced liver injury (AT-DILI) remain unclear. Isoniazid and rifampicin may lead to hepatic accumulation of protoporphyrin IX in which heme synthesis ferrochelatase (FECH), a key rate-limiting enzyme, potentially plays an important role. This study aimed to investigate the combined effects of FECH gene polymorphisms and promoter methylation on AT-DILI...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41242711
DOI: 10.1097/FPC.0000000000000583

Genes

FECH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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