Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The role of the genetic variant FECH rs11660001 in the occurrence of anti-tuberculosis drug-induced liver injury.

Journal of clinical pharmacy and therapeutics - 1 Aug 2022

Zhang Meiling, Zhu Jia, Wang Nannan, Liu Wenpei, Lu Lihuan, Pan Hongqiu, He Xiaomin, Yi Honggang, Tang Shaowen

Abstract excerpt

WHAT IS KNOWN AND OBJECTIVE: The pathogenic mechanism of anti-tuberculosis drug-induced liver injury (AT-DILI) is still largely unknown. Recent studies have indicated that rifampicin and isoniazid cotreatment causes the accumulation of endogenous protoporphyrin IX in the liver through the haem biosynthesis pathway. Alanine synthase 1 (ALAS1) and ferrochelatase (FECH) are the rate-limiting enzymes in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antitubercular Agents
Share to Case-Control Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chemical and Drug Induced Liver Injury

Share to Ferrochelatase

Share to Genetic Predisposition to Disease

Share to Polymorphism, Single Nucleotide

Share to Tuberculosis

Source

Identifiers

PMID: 35470464
DOI: 10.1111/jcpt.13672

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The role of the genetic variant FECH rs11660001 in the occurrence of anti-tuberculosis drug-induced liver injury.PMID 35470464Read ↗

No interaction between genetic variants and DNA methylation of the ferrochelatase gene in relation to antituberculosis drug-induced liver injury.Semantic proximity Read ↗

Genome-wide association and replication study of anti-tuberculosis drugs-induced liver toxicitySemantic proximity Read ↗

Association of POR and PPARα polymorphisms with risk of anti-tuberculosis drug-induced liver injury in Western Chinese Han population.Semantic proximity Read ↗

Study on the relationship between liver damage caused by anti-tuberculosis drug rifampicin and related metabolic enzyme gene polymorphismsSemantic proximity Read ↗

Association of Gene Polymorphisms and Serum Levels of ALAS1 with the Risk of Anti-Tuberculosis Drug-Induced Liver Injury.Semantic proximity Read ↗

Prospective study of ALDH1A1 gene polymorphisms associated with antituberculosis drug-induced liver injury in western Chinese Han population.Semantic proximity Read ↗

Study on the associations between liver damage and antituberculosis drug rifampicin and relative metabolic enzyme gene polymorphisms.Semantic proximity Read ↗

Association of ABCG2 polymorphisms with susceptibility to anti-tuberculosis drug-induced hepatotoxicity in the Chinese population.Semantic proximity Read ↗

Association of ABCB6 Polymorphisms and Serum Levels with Susceptibility to Antituberculosis Drug-induced Hepatotoxicity.Semantic proximity Read ↗

Polymorphism of PXR gene associated with the increased risk of drug-induced liver injury in Indonesian pulmonary tuberculosis patients.Semantic proximity Read ↗

Relationship between xanthine oxidase gene polymorphisms and anti-tuberculosis drug-induced liver injury in a Chinese population.Semantic proximity Read ↗

The association of CpG island DNA methylation in the promoter region, genetic polymorphism of ALAS1 with anti-tuberculosis drug-induced liver injurySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.