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Prospective study of ALDH1A1 gene polymorphisms associated with antituberculosis drug-induced liver injury in western Chinese Han population.

Microbiology and immunology - 1 Apr 2021

Peng Wu, Zhao Zhen-Zhen, Jiao Lin, Wu Tao, Chen Hao, Zhang Chun-Ying, Song Jia-Jia, Liu Tang-Yu-Heng, Wu Li-Juan, Wang Min-Jin, Chen Jie, Zhou Yi, Ying Bin-Wu

Abstract excerpt

Antituberculosis drug-induced liver injury (ATDILI) has received increasing attention globally, which may limit the effectiveness of antituberculosis (anti-TB) treatment. Many host genetic determinants of ATDILI have been identified recently. As little knowledge is currently available about the association between aldehyde dehydrogenase 1 family member A1 (ALDH1A1) polymorphisms and ATDILI, the association...

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PMID: 33527427
DOI: 10.1111/1348-0421.12877

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