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An <i>IGHG1</i> Variant Introgressed From Vindija Neanderthal Archaic Hominin Confers Enhanced Antibody Immunity Against SARS-CoV-2

2022-05-07

Abstract excerpt

How genetic polymorphisms of adaptive immune receptors influence population susceptibility to infectious diseases remains unclear. Here we describe the prevalence and provenance of a coding variant in IgG1 (G396R) that influences the IgG1 antibody response against SARS-CoV-2. G396R variant is negatively associated with susceptibility to COVID-19. The protective effect of the G396R variant is achieved by promoting...

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Literature Corpus work
64004130-c56b-5426-bf02-6a814522fd45
DOI
10.2139/ssrn.4102635
Open publication

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An <i>IGHG1</i> Variant Introgressed From Vindija Neanderthal Archaic Hominin Confers Enhanced Antibody Immunity Against SARS-CoV-2DOI 10.2139/ssrn.4102635
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