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Maternal <i>IGHG</i> locus duplications impair infants’ passive immunity

2025-10-10

Abstract excerpt

Infants depend on passive immunity to safeguard them against infections during the first months of life. Maternal immunoglobulin G (IgG) antibodies are actively transported across the placenta and confer this protection. In this study, we discovered common, but previously unrecognized, naturally occurring gene fusions between loci encoding IgG1 and IgG4 subclasses that impair the transplacental IgG transport. Thes...

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Literature Corpus work
a4a7fa02-e39e-5f4b-9a28-81290133a29b
DOI
10.1101/2025.10.09.25337669
Open publication

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Maternal <i>IGHG</i> locus duplications impair infants’ passive immunityDOI 10.1101/2025.10.09.25337669
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