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Article

An autoimmune disease variant of IgG1 modulates B cell activation and differentiation

4 Oct 2018

Abstract excerpt

An IgG1 SNP enhances autoimmunity One common feature of autoimmune diseases like systemic lupus erythematosus (SLE) is the presence of high titers of self-reactive antibodies. These result in immune complexes, inflammation, and tissue pathology. Consequently, the checkpoints that normally keep immunoglobulin G (IgG)–positive autoreactive B cells in check are of intense interest. Chen et al. report the presence of...

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PMID: 30287618
DOI: 10.1126/science.aap9310

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