Article

S100A8/A9 innate immune signaling as a distinct mechanism driving progression of smoking-related breast cancers

2024-07-12

Abstract excerpt

<title>Abstract</title> <p>Smoking plays an underappreciated role in breast cancer progression, increasing recurrence and mortality in patients. Here, we show that S100A8/A9 innate immune signaling is a molecular mechanism that identifies smoking-related breast cancers and underlies their enhanced malignancy. In contrast to acute exposure, chronic nicotine increased tumorigenicity and reprogrammed breast cancer c...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 54caebbc-78e3-55d6-91bc-f8db7826c79e
DOI: 10.21203/rs.3.rs-4559578/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

S100A8/A9 innate immune signaling as a distinct mechanism driving progression of smoking-related breast cancersDOI 10.21203/rs.3.rs-4559578/v1Read

Large scale analysis of smoking-induced changes in the tumor immune microenvironmentSemantic proximity Read

Investigation of the α9-nicotinic receptor single nucleotide polymorphisms induced oncogenic properties and molecular mechanisms in breast cancer.Semantic proximity Read

Breastfeeding Shapes a Unique Tumor-Immune Landscape in Pregnancy-Associated Breast Cancer from GEICAM-EMBARCAM studySemantic proximity Read

Smoking-associated gene expression alterations in nasal epithelium reveal immune impairment linked to lung cancer riskSemantic proximity Read

Smoking correlates with increased cytoskeletal protein-related coding region mutations in the lung and head and neck datasets of the cancer genome atlas.Semantic proximity Read

An Immune-Inflammation Gene Expression Signature in Prostate Tumors of SmokersSemantic proximity Read

Smoking-dependent expression alterations in nasal epithelium reveal immune impairment linked to germline variation and lung cancer riskSemantic proximity Read

Tobacco Smoking-Associated Alterations in the Immune Microenvironment of Squamous Cell Carcinomas.Semantic proximity Read

Artificial intelligence-based epigenomic, transcriptomic and histologic signatures of tobacco use in oral squamous cell carcinomaSemantic proximity Read

Highly homologous hS100A15 and hS100A7 proteins are distinctly expressed in normal breast tissue and breast cancerSemantic proximity Read

Neuroendocrine pathways and breast cancer progression: a pooled analysis of somatic mutations and gene expression from two large breast cancer cohorts.Semantic proximity Read

Nicotinic receptors atlas in the adult human lungSemantic proximity Read