Naturally occurring variants of human Α9 nicotinic receptor differentially affect bronchial cell proliferation and transformation.

doi:10.1371/journal.pone.0027978

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Article

Naturally occurring variants of human Α9 nicotinic receptor differentially affect bronchial cell proliferation and transformation.

PloS one - 1 Jan 2011

Chikova Anna, Grando Sergei A

Abstract excerpt

Isolation of polyadenilated mRNA from human immortalized bronchial epithelial cell line BEP2D revealed the presence of multiple isoforms of RNA coded by the CHRNA9 gene for α9 nicotinic acetylcholine receptor (nAChR). BEP2D cells were homozygous for the rs10009228 polymorphism encoding for N442S amino acid substitution, and also contained mRNA coding for several truncated isoforms of α9 protein. To elucidate the...

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PMID: 22125646
DOI: 10.1371/journal.pone.0027978
PMCID: PMC3220719

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CHRNA9

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