Article
Geographic differences in genetic susceptibility to IgA nephropathy: GWAS replication study and geospatial risk analysis.
PLoS genetics - 1 Jan 2012
Kiryluk Krzysztof, Li Yifu, Sanna-Cherchi Simone, Rohanizadegan Mersedeh, Suzuki Hitoshi, Eitner Frank, Snyder Holly J, Choi Murim, Hou Ping, Scolari Francesco, Izzi Claudia, Gigante Maddalena, Gesualdo Loreto, Savoldi Silvana, Amoroso Antonio, Cusi Daniele, Zamboli Pasquale, Julian Bruce A, Novak Jan, Wyatt Robert J, Mucha Krzysztof, Perola Markus, Kristiansson Kati, Viktorin Alexander, Magnusson Patrik K, Thorleifsson Gudmar, Thorsteinsdottir Unnur, Stefansson Kari, Boland Anne, Metzger Marie, Thibaudin Lise, Wanner Christoph, Jager Kitty J, Goto Shin, Maixnerova Dita, Karnib Hussein H, Nagy Judit, Panzer Ulf, Xie Jingyuan, Chen Nan, Tesar Vladimir, Narita Ichiei, Berthoux Francois, Floege Jürgen, Stengel Benedicte, Zhang Hong, Lifton Richard P, Gharavi Ali G
Abstract excerpt
IgA nephropathy (IgAN), major cause of kidney failure worldwide, is common in Asians, moderately prevalent in Europeans, and rare in Africans. It is not known if these differences represent variation in genes, environment, or ascertainment. In a recent GWAS, we localized five IgAN susceptibility...
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