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Article

Allele specificity of DNA replication timing in the Angelman/Prader-Willi syndrome imprinted chromosomal region.

Nature genetics - 1 Jan 1994

Knoll J H, Cheng S D, Lalande M

Abstract excerpt

DNA replication within chromosome 15q11-q13, a region subject to genomic imprinting, was examined by fluorescence in situ hybridization. Asynchronous replication between homologues was observed in cells from normal individuals and in Prader-Willi (PWS) and Angelman syndrome (AS) patients with chromosome 15 deletions but not in PWS patients with maternal uniparental disomy. Opposite patterns of allele-specific...

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Share to Alleles
Share to Chromosomes, Human, Pair 15
Share to DNA Replication

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to In Situ Hybridization, Fluorescence

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Source

Identifiers

PMID: 8136833
DOI: 10.1038/ng0194-41

Genes

GABRA5
GABRB3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Allele specificity of DNA replication timing in the Angelman/Prader-Willi syndrome imprinted chromosomal region.PMID 8136833Read ↗

Flow cytometry and FISH to investigate allele-specific replication timing and homologous association of imprinted chromosomes.Semantic proximity Read ↗

Domain organization of allele-specific replication within the GABRB3 gene cluster requires a biparental 15q11-13 contribution.Semantic proximity Read ↗

Parent-of-origin-specific DNA replication timing is confined to large imprinted regions.Semantic proximity Read ↗

Identification of a putative DNA replication origin in the gamma-aminobutyric acid receptor subunit beta3 and alpha5 gene cluster on human chromosome 15q11-q13, a region associated with parental imprinting and allele-specific replication timing.Semantic proximity Read ↗

Homologous association of oppositely imprinted chromosomal domains.Semantic proximity Read ↗

Allele-specific replication timing in imprinted domains: absence of asynchrony at several loci.Semantic proximity Read ↗

Allele-specific replication of 15q11-q13 loci: a diagnostic test for detection of uniparental disomy.Semantic proximity Read ↗

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Relaxation of imprinting in Prader-Willi syndrome.Semantic proximity Read ↗

Prader-Willi and Angelman syndromes. Disorders of genomic imprinting.Semantic proximity Read ↗

DNA replication asynchrony between the paternal and maternal alleles of imprinted genes does not straddle the R/G transition.Semantic proximity Read ↗

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