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Article

Allele specificity of DNA replication timing in the Angelman/Prader-Willi syndrome imprinted chromosomal region.

Nature genetics - 1 Jan 1994

Knoll J H, Cheng S D, Lalande M

Abstract excerpt

DNA replication within chromosome 15q11-q13, a region subject to genomic imprinting, was examined by fluorescence in situ hybridization. Asynchronous replication between homologues was observed in cells from normal individuals and in Prader-Willi (PWS) and Angelman syndrome (AS) patients with chromosome 15 deletions but not in PWS patients with maternal uniparental disomy. Opposite patterns of allele-specific...

Topics

Alleles
Angelman Syndrome
Chromosomes, Human, Pair 15
DNA Replication
Female
Genetic Markers
Humans
In Situ Hybridization, Fluorescence
Male
Mosaicism
Parents
Pedigree

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Prader-Willi Syndrome

Receptors, GABA-A

Receptors, GABA-B

Time Factors

Source

Identifiers

PMID: 8136833
DOI: 10.1038/ng0194-41

Genes

GABRA5
GABRB3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8136833-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Click a neighbor to travelStep 1 · 12 closest

Allele specificity of DNA replication timing in the Angelman/Prader-Willi syndrome imprinted chromosomal region.PMID 8136833Read ↗

Flow cytometry and FISH to investigate allele-specific replication timing and homologous association of imprinted chromosomes.Semantic proximity Read ↗

Domain organization of allele-specific replication within the GABRB3 gene cluster requires a biparental 15q11-13 contribution.Semantic proximity Read ↗

Parent-of-origin-specific DNA replication timing is confined to large imprinted regions.Semantic proximity Read ↗

Identification of a putative DNA replication origin in the gamma-aminobutyric acid receptor subunit beta3 and alpha5 gene cluster on human chromosome 15q11-q13, a region associated with parental imprinting and allele-specific replication timing.Semantic proximity Read ↗

Homologous association of oppositely imprinted chromosomal domains.Semantic proximity Read ↗

Allele-specific replication timing in imprinted domains: absence of asynchrony at several loci.Semantic proximity Read ↗

Allele-specific replication of 15q11-q13 loci: a diagnostic test for detection of uniparental disomy.Semantic proximity Read ↗

Mechanisms of imprinting of the Prader–Willi/Angelman regionSemantic proximity Read ↗

Relaxation of imprinting in Prader-Willi syndrome.Semantic proximity Read ↗

Prader-Willi and Angelman syndromes. Disorders of genomic imprinting.Semantic proximity Read ↗

DNA replication asynchrony between the paternal and maternal alleles of imprinted genes does not straddle the R/G transition.Semantic proximity Read ↗

Imprinting mutations suggested by abnormal DNA methylation patterns in familial Angelman and Prader-Willi syndromes.Semantic proximity Read ↗

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