Article

Kindlin-2 preserves integrity of the articular cartilage to protect against osteoarthritis

2021-08-12

Abstract excerpt

Osteoarthritis (OA) is an aging-related degenerative joint disease, which has no cure partly due to limited understanding of its pathological mechanism(s). Here we report that the focal adhesion protein Kindlin-2, but not Kindlin-1 or −3, is highly expressed in articular chondrocytes of the hyaline cartilage, which is dramatically decreased in the degenerated articular cartilage of aged mice and patients with OA....

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Literature Corpus work: 6ee29006-14c6-53ad-a531-ebf4e14d5a6e
DOI: 10.1101/2021.08.11.456023

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