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Article

Regulation of fibroblast phenotype in osteoarthritis using CDKN1A-loaded copper sulfide nanoparticles delivered by mesenchymal stem cells.

American journal of physiology. Cell physiology - 1 Feb 2025

Liu Hong, Ji Ming, Yang Tao, Zou Shihua, Qiu Xingan, Zhan Fangbiao, Chen Jian, Yan Fei, Ding Fan, Li Ping

Abstract excerpt

This study aimed to investigate the regulation of fibroblast phenotypes by mesenchymal stem cells (MSCs) delivering copper sulfide (CuS) nanoparticles (NPs) loaded with CDKN1A plasmids and their role in cartilage repair during osteoarthritis (OA). Single-cell RNA sequencing data from the GEO database were analyzed to identify subpopulations within the OA immune microenvironment. Quality control, filtering,...

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Identifiers

PMID: 39819042
DOI: 10.1152/ajpcell.00573.2024

Genes

CDKN1A
MMP13
MSC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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