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Article

A Stem Cell–Based Approach to Cartilage Repair

6 Apr 2012

Abstract excerpt

Osteoarthritis (OA) is a degenerative joint disease that involves the destruction of articular cartilage and eventually leads to disability. Molecules that promote the selective differentiation of multipotent mesenchymal stem cells (MSCs) into chondrocytes may stimulate the repair of damaged cartilage. Using an image-based high-throughput screen, we identified the small molecule kartogenin, which promotes...

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PMID: 22491093
DOI: 10.1126/science.1215157

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