Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutations in ArgS Arginine-tRNA Synthetase Confer Additional Antibiotic Tolerance Protection to Extended-Spectrum-β-Lactamase-Producing Burkholderia thailandensis.

Antimicrobial agents and chemotherapy - 21 May 2020

Yi Hyojeong, Park Jongwook, Cho Kwang-Hwi, Kim Heenam Stanley

Abstract excerpt

Highly conserved PenI-type class A β-lactamase in pathogenic members of Burkholderia species can evolve to extended-spectrum β-lactamase (ESBL), which exhibits hydrolytic activity toward third-generation cephalosporins, while losing its activity toward the original penicillin substrates. We describe three single-amino-acid-substitution mutations in the ArgS arginine-tRNA synthetase that confer extra antibiotic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acyl-tRNA Synthetases
Share to Anti-Bacterial Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Arginine

Share to beta-Lactamases

Share to Burkholderia

Share to Immune Tolerance

Share to Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 32205346
DOI: 10.1128/AAC.02252-19
PMCID: PMC7269490

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutations in ArgS Arginine-tRNA Synthetase Confer Additional Antibiotic Tolerance Protection to Extended-Spectrum-β-Lactamase-Producing Burkholderia thailandensis.PMID 32205346Read ↗

Bacterial persistence to antibiotics activated by tRNA mutations.Semantic proximity Read ↗

Mutations in MetG (methionyl-tRNA synthetase) and TrmD [tRNA (guanine-N1)-methyltransferase] conferring meropenem tolerance in Burkholderia thailandensis.Semantic proximity Read ↗

Pyrrolysyl-tRNA synthetase variants reveal ancestral aminoacylation function.Semantic proximity Read ↗

Characterization of Two Seryl-tRNA Synthetases in Albomycin-Producing <i>Streptomyces</i> sp. Strain ATCC 700974Semantic proximity Read ↗

High adaptability of the omega loop underlies the substrate-spectrum-extension evolution of a class A β-lactamase, PenL.Semantic proximity Read ↗

A tRNAModification-based strategy for Identifying amiNo acid Overproducers (AMINO).Semantic proximity Read ↗

Fine-Tuning of Alanyl-tRNA Synthetase Quality Control Alleviates Global Dysregulation of the Proteome.Semantic proximity Read ↗

Single amino acid changes in AspRS reveal alternative routes for expanding its tRNA repertoire in vivo.Semantic proximity Read ↗

Modular pathways for editing non-cognate amino acids by human cytoplasmic leucyl-tRNA synthetase.Semantic proximity Read ↗

Elucidation of tRNA-dependent editing by a class II tRNA synthetase and significance for cell viability.Semantic proximity Read ↗

Two-Tier Screening Platform for Directed Evolution of Aminoacyl-tRNA Synthetases with Enhanced Stop Codon Suppression Efficiency.Semantic proximity Read ↗

Stereochemical basis for engineered pyrrolysyl-tRNA synthetase and the efficient in vivo incorporation of structurally divergent non-native amino acids.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.