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Article

Large mutational target size for rapid emergence of bacterial persistence.

Proceedings of the National Academy of Sciences of the United States of America - 31 Jul 2012

Girgis Hany S, Harris Kendra, Tavazoie Saeed

Abstract excerpt

Phenotypic heterogeneity displayed by a clonal bacterial population permits a small fraction of cells to survive prolonged exposure to antibiotics. Although first described over 60 y ago, the molecular mechanisms underlying this behavior, termed persistence, remain largely unknown. To systematically explore the genetic basis of persistence, we selected a library of transposon-mutagenized Escherichia coli cells...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22802628
DOI: 10.1073/pnas.1205124109
PMCID: PMC3411964

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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