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Mycobacterium Lysine ε-aminotransferase is a novel alarmone metabolism related persister gene via dysregulating the intracellular amino acid level.

Scientific reports - 25 Jan 2016

Duan Xiangke, Li Yunsong, Du Qinglin, Huang Qinqin, Guo Siyao, Xu Mengmeng, Lin Yanping, Liu Zhidong, Xie Jianping

Abstract excerpt

Bacterial persisters, usually slow-growing, non-replicating cells highly tolerant to antibiotics, play a crucial role contributing to the recalcitrance of chronic infections and treatment failure. Understanding the molecular mechanism of persister cells formation and maintenance would obviously inspire the discovery of new antibiotics. The significant upregulation of Mycobacterium tuberculosis Rv3290c, a highly...

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PMID: 26806099
DOI: 10.1038/srep19695
PMCID: PMC4726150

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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