Article
Mutations in respiratory complex I promote antibiotic persistence through alterations in intracellular acidity and protein synthesis.
Nature communications - 27 Jan 2022
Van den Bergh Bram, Schramke Hannah, Michiels Joran Elie, Kimkes Tom E P, Radzikowski Jakub Leszek, Schimpf Johannes, Vedelaar Silke R, Burschel Sabrina, Dewachter Liselot, Lončar Nikola, Schmidt Alexander, Meijer Tim, Fauvart Maarten, Friedrich Thorsten, Michiels Jan, Heinemann Matthias
Abstract excerpt
Antibiotic persistence describes the presence of phenotypic variants within an isogenic bacterial population that are transiently tolerant to antibiotic treatment. Perturbations of metabolic homeostasis can promote antibiotic persistence, but the precise mechanisms are not well understood. Here, we use laboratory evolution, population-wide sequencing and biochemical characterizations to identify mutations in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.