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Role of Epithelial-Mesenchymal Transition in Retinal Pigment Epithelium Dysfunction

25 Jun 2020

Abstract excerpt

Retinal pigment epithelial (RPE) cells maintain the health and functional integrity of both photoreceptors and the choroidal vasculature. Loss of RPE differentiation has long been known to play a critical role in numerous retinal diseases, including inherited rod-cone degenerations, inherited macular degeneration, age-related macular degeneration, and proliferative vitreoretinopathy. Recent studies in post-mortem...

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PMID: 32671066
DOI: 10.3389/fcell.2020.00501

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