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Article

MED12 loss activates endogenous retroelements to sensitise immunotherapy in pancreatic cancer

31 Aug 2024

Abstract excerpt

Objective Pancreatic ductal adenocarcinoma (PDAC) stands as one of the most lethal cancers, marked by its lethality and limited treatment options, including the utilisation of checkpoint blockade (ICB) immunotherapy. Epigenetic dysregulation is a defining feature of tumourigenesis that is implicated in immune surveillance, but remains elusive in PDAC. Design To identify the factors that modulate immune...

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PMID: 39216984
DOI: 10.1136/gutjnl-2024-332350

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