Article

Tissue-resident natural killer cells support survival in pancreatic cancer through promotion of cDC1-CD8 T activity

2024-11-07

Abstract excerpt

The immunosuppressive microenvironment in pancreatic ductal adenocarcinoma (PDAC) prevents tumor control and strategies to restore anti-cancer immunity (i.e. by increasing CD8 T-cell activity) have had limited success. Here, we demonstrate how inducing localized physical damage using ionizing radiation (IR) unmasks the benefit of immunotherapy by increasing tissue-resident natural killer (trNK) cells that support...

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Literature Corpus work: 39acb7a6-ee6a-5627-b6c9-7a57535b01ca
DOI: 10.7554/elife.92672.3

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