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Article

Epigenetic and Transcriptional Control of the Epidermal Growth Factor Receptor Regulates the Tumor Immune Microenvironment in Pancreatic Cancer.

Cancer discovery - 1 Mar 2021

Li Jinyang, Yuan Salina, Norgard Robert J, Yan Fangxue, Sun Yu H, Kim Il-Kyu, Merrell Allyson J, Sela Yogev, Jiang Yanqing, Bhanu Natarajan V, Garcia Benjamin A, Vonderheide Robert H, Blanco Andrés, Stanger Ben Z

Abstract excerpt

Although immunotherapy has revolutionized cancer care, patients with pancreatic ductal adenocarcinoma (PDA) rarely respond to these treatments, a failure that is attributed to poor infiltration and activation of T cells in the tumor microenvironment (TME). We performed an in vivo CRISPR screen and identified lysine demethylase 3A (KDM3A) as a potent epigenetic regulator of immunotherapy response in PDA....

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Source

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Identifiers

PMID: 33158848
DOI: 10.1158/2159-8290.CD-20-0519
PMCID: PMC7933070

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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