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Article

Enpp1 mutations promote upregulation of hedgehog signaling in heterotopic ossification with aging.

Journal of bone and mineral metabolism - 1 Nov 2024

He Zhongyuan, Zhu Zhengya, Tang Tao, Wang Fuan, Guo Peng, Li Jianfeng, Tung Nguyen Tran Canh, Liang Qian, Liu Shaoyu, Gao ManMan, Liu Xizhe, Zhou Zhiyu

Abstract excerpt

INTRODUCTION: Heterotopic ossification of the tendon and ligament (HOTL) is a chronic progressive disease that is usually accompanied by thickening and ossification of ligaments and high osteogenic activity of the surrounding ligament tissue. However, the molecular mechanism of maintaining the cellular phenotype of HOTL remains unclear. MATERIALS AND METHODS: We first constructed a model of HOTL,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 39212714
DOI: 10.1007/s00774-024-01543-1
PMCID: PMC11632054

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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