Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Enpp1 inhibits ectopic joint calcification and maintains articular chondrocytes by repressing hedgehog signaling

15 Aug 2018

Abstract excerpt

ABSTRACT The differentiated phenotype of articular chondrocytes of synovial joints needs to be maintained throughout life. Disruption of the articular cartilage, frequently associated with chondrocyte hypertrophy and calcification, is a central feature in osteoarthritis (OA). However, the molecular mechanisms whereby phenotypes of articular chondrocytes are maintained and pathological calcification is inhibited...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related gene regulation
Share to Hedgehog Signaling Pathway Studies
Share to Osteoarthritis Treatment and Mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30111653
DOI: 10.1242/dev.164830

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Enpp1 inhibits ectopic joint calcification and maintains articular chondrocytes by repressing hedgehog signalingPMID 30111653Read ↗

Enpp1 mutations promote upregulation of hedgehog signaling in heterotopic ossification with aging.Semantic proximity Read ↗

Chondrogenesis mediated by PPi depletion promotes spontaneous aortic calcification in NPP1-/- mice.Semantic proximity Read ↗

Arterial calcification is driven by RAGE in Enpp1-/- mice.Semantic proximity Read ↗

Loss of skeletal mineralization by the simultaneous ablation of PHOSPHO1 and alkaline phosphatase function: a unified model of the mechanisms of initiation of skeletal calcification.Semantic proximity Read ↗

Zebrafish enpp1 mutants exhibit pathological mineralization, mimicking features of generalized arterial calcification of infancy (GACI) and pseudoxanthoma elasticum (PXE).Semantic proximity Read ↗

A new Enpp1 allele, Enpp1(ttw-Ham), identified in an ICR closed colony.Semantic proximity Read ↗

Elastin Haploinsufficiency Impedes the Progression of Arterial Calcification in MGP-Deficient MiceSemantic proximity Read ↗

Primary cilia drive postnatal tidemark patterning in articular cartilage by coordinating responses to Indian Hedgehog and mechanical loadSemantic proximity Read ↗

The prevalence of ENPP1 deficiency and the preclinical efficacy of ENPP1 biologic therapy in OPLL.Semantic proximity Read ↗

Silencing SGK1 alleviates osteoarthritis through epigenetic regulation of CREB1 and ABCA1 expressionSemantic proximity Read ↗

A mouse model of Jansen's metaphyseal chondrodysplasia for investigating disease mechanisms and candidate therapeutics.Semantic proximity Read ↗

Hematopoietic PBX-interacting protein mediates cartilage degeneration during the pathogenesis of osteoarthritisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.