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Article

FOXO are required for intervertebral disk homeostasis during aging and their deficiency promotes disk degeneration

2 Jul 2018

Abstract excerpt

Intervertebral disk (IVD) degeneration is a prevalent age-associated musculoskeletal disorder and a major cause of chronic low back pain. Aging is the main risk factor for the disease, but the molecular mechanisms regulating IVD homeostasis during aging are unknown. The aim of this study was to investigate the function of FOXO, a family of transcription factors linked to aging and longevity, in IVD aging and...

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PMID: 29963746
DOI: 10.1111/acel.12800

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