Article
Tenomodulin knockout mice exhibit worse late healing outcomes with augmented trauma-induced heterotopic ossification of Achilles tendon.
Cell death & disease - 5 Nov 2021
Delgado Caceres Manuel, Angerpointner Katharina, Galler Michael, Lin Dasheng, Michel Philipp A, Brochhausen Christoph, Lu Xin, Varadarajan Adithi R, Warfsmann Jens, Stange Richard, Alt Volker, Pfeifer Christian G, Docheva Denitsa
Abstract excerpt
Heterotopic ossification (HO) represents a common problem after tendon injury with no effective treatment yet being developed. Tenomodulin (Tnmd), the best-known mature marker for tendon lineage cells, has important effects in tendon tissue aging and function. We have reported that loss of Tnmd leads to inferior early tendon repair characterized by fibrovascular scaring and therefore hypothesized that its lack...
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