Article

The prevalence of ENPP1 deficiency and the preclinical efficacy of ENPP1 biologic therapy in OPLL.

2024-10-24

Abstract excerpt

<title>Abstract</title> <p>Ossification of the Posterior Longitudinal Ligament (OPLL) and Diffuse Idiopathic Skeletal Hyperostosis (DISH) are disorders in which patients suffer from pain and stiffness due to progressive spinal fractures and enthesospathy. Myelopathy and impaired mobility worsen with age and may progress to hemiplegia; the mechanisms driving disease progression are unknown, and effective treatment...

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Literature Corpus work: 4acc61fa-06b7-592a-8eb7-0dccdfe69bb3
DOI: 10.21203/rs.3.rs-5205902/v1

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