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Whole genome sequencing reveals the mutational landscape from disease diagnosis to relapse in patients with childhood acute myeloid leukaemia.

The Malaysian journal of pathology - 1 Aug 2024

Aziz H, Ab Mutalib N S, Alias H, Jamal R

Abstract excerpt

INTRODUCTION: Leukaemia is the most common cancer in children, however, there is still a big gap in knowledge about the genomic alterations in childhood acute myeloid leukaemia (AML) compared to adult AML. Relapsed AML remains as a leading cause of cancer deaths among children. This study aims to understand the molecular mechanisms of relapsed AML by elucidating the mutational landscape before and during relapse....

Topics

Humans
Leukemia, Myeloid, Acute
Child
Male
Mutation
Female
Whole Genome Sequencing
Child, Preschool
Adolescent
Infant
Neoplasm Recurrence, Local

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39207003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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