Article
Next-generation-sequencing of recurrent childhood high hyperdiploid acute lymphoblastic leukemia reveals mutations typically associated with high risk patients.
Leukemia research - 1 Sept 2015
Chen Cai, Bartenhagen Christoph, Gombert Michael, Okpanyi Vera, Binder Vera, Röttgers Silja, Bradtke Jutta, Teigler-Schlegel Andrea, Harbott Jochen, Ginzel Sebastian, Thiele Ralf, Husemann Peter, Krell Pina F I, Borkhardt Arndt, Dugas Martin, Hu Jianda, Fischer Ute
Abstract excerpt
20% of children suffering from high hyperdiploid acute lymphoblastic leukemia develop recurrent disease. The molecular mechanisms are largely unknown. Here, we analyzed the genetic landscape of five patients at relapse, who developed recurrent disease without prior high-risk indication using whole-exome- and whole-genome-sequencing. Oncogenic mutations of RAS pathway genes (NRAS, KRAS, FLT3, n=4) and deactivating...
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