Article
Genomic Profiling of Pediatric Acute Myeloid Leukemia Reveals a Changing Mutational Landscape from Disease Diagnosis to Relapse.
Cancer research - 15 Apr 2016
Farrar Jason E, Schuback Heather L, Ries Rhonda E, Wai Daniel, Hampton Oliver A, Trevino Lisa R, Alonzo Todd A, Guidry Auvil Jaime M, Davidsen Tanja M, Gesuwan Patee, Hermida Leandro, Muzny Donna M, Dewal Ninad, Rustagi Navin, Lewis Lora R, Gamis Alan S, Wheeler David A, Smith Malcolm A, Gerhard Daniela S, Meshinchi Soheil
Abstract excerpt
The genomic and clinical information used to develop and implement therapeutic approaches for acute myelogenous leukemia (AML) originated primarily from adult patients and has been generalized to patients with pediatric AML. However, age-specific molecular alterations are becoming more evident and may signify the need to age-stratify treatment regimens. The NCI/COG TARGET-AML initiative used whole exome capture...
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