Article
Whole-exome sequencing reveals the spectrum of gene mutations and the clonal evolution patterns in paediatric acute myeloid leukaemia.
British journal of haematology - 1 Nov 2016
Shiba Norio, Yoshida Kenichi, Shiraishi Yuichi, Okuno Yusuke, Yamato Genki, Hara Yusuke, Nagata Yasunobu, Chiba Kenichi, Tanaka Hiroko, Terui Kiminori, Kato Motohiro, Park Myoung-Ja, Ohki Kentaro, Shimada Akira, Takita Junko, Tomizawa Daisuke, Kudo Kazuko, Arakawa Hirokazu, Adachi Souichi, Taga Takashi, Tawa Akio, Ito Etsuro, Horibe Keizo, Sanada Masashi, Miyano Satoru, Ogawa Seishi, Hayashi Yasuhide
Abstract excerpt
Acute myeloid leukaemia (AML) is a molecularly and clinically heterogeneous disease. Targeted sequencing efforts have identified several mutations with diagnostic and prognostic values in KIT, NPM1, CEBPA and FLT3 in both adult and paediatric AML. In addition, massively parallel sequencing enabled the discovery of recurrent mutations (i.e. IDH1/2 and DNMT3A) in adult AML. In this study, whole-exome sequencing...
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