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Article

Effects of PCNA Stability on the Formation of Mutations.

International journal of molecular sciences - 8 Aug 2024

Arbel-Groissman Matan, Liefshitz Batia, Kupiec Martin

Abstract excerpt

The fidelity of replication, especially in the presence of DNA damage, is essential for the proper function of cells. Mutations that inactivate genes involved in DNA damage repair or bypass are enriched in several types of cancer cells. Thus, it is important to further our understanding of the mechanisms governing replication fidelity. PCNA is a ring-shaped complex that encircles DNA at the front of the...

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Identifiers

PMID: 39201337
DOI: 10.3390/ijms25168646
PMCID: PMC11354803

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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