Nuclear dynamics of PCNA in DNA replication and repair.

doi:10.1128/MCB.25.21.9350-9359.2005

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Article

Nuclear dynamics of PCNA in DNA replication and repair.

Molecular and cellular biology - 1 Nov 2005

Essers Jeroen, Theil Arjan F, Baldeyron Céline, van Cappellen Wiggert A, Houtsmuller Adriaan B, Kanaar Roland, Vermeulen Wim

Abstract excerpt

The DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) is central to both DNA replication and repair. The ring-shaped homotrimeric PCNA encircles and slides along double-stranded DNA, acting as a "sliding clamp" that localizes proteins to DNA. We determined the behavior of green fluorescent protein-tagged human PCNA (GFP-hPCNA) in living cells to analyze its different engagements in DNA...

Topics

Animals
CHO Cells
Cell Cycle
Cell Nucleus
Cricetinae
Cricetulus
DNA Damage
DNA Repair
DNA Replication
Green Fluorescent Proteins
Humans
Mutation
Photobleaching
Proliferating Cell Nuclear Antigen
Protein Transport
Ultraviolet Rays

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Open in PubMed Open full text

Identifiers

PMID: 16227586
DOI: 10.1128/MCB.25.21.9350-9359.2005
PMCID: PMC1265825

Genes

PCNA

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