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Article

Sarcomeres regulate murine cardiomyocyte maturation through MRTF-SRF signaling.

Proceedings of the National Academy of Sciences of the United States of America - 12 Jan 2021

Guo Yuxuan, Cao Yangpo, Jardin Blake D, Sethi Isha, Ma Qing, Moghadaszadeh Behzad, Troiano Emily C, Mazumdar Neil, Trembley Michael A, Small Eric M, Yuan Guo-Cheng, Beggs Alan H, Pu William T

Abstract excerpt

The paucity of knowledge about cardiomyocyte maturation is a major bottleneck in cardiac regenerative medicine. In development, cardiomyocyte maturation is characterized by orchestrated structural, transcriptional, and functional specializations that occur mainly at the perinatal stage. Sarcomeres are the key cytoskeletal structures that regulate the ultrastructural maturation of other organelles, but whether...

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Identifiers

PMID: 33361330
DOI: 10.1073/pnas.2008861118
PMCID: PMC7812832

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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