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Article

Overlapping peri-implantation phenotypes of ZNHIT1 and ZNHIT2 despite distinct functions during early mouse development†.

Biology of reproduction - 11 Nov 2024

He Xinjian Doris, Taylor Louis F, Miao Xiaosu, Shi Yingchao, Lin Xinhua, Yang Zhongzhou, Liu Xin, Miao Yi-Liang, Alfandari Dominique, Cui Wei, Tremblay Kimberly D, Mager Jesse

Abstract excerpt

Mammalian preimplantation development culminates in the formation of a blastocyst that undergoes extensive gene expression regulation to successfully implant into the maternal endometrium. Zinc-finger HIT domain-containing (ZNHIT) 1 and 2 are members of a highly conserved family, yet they have been identified as subunits of distinct complexes. Here, we report that knockout of either Znhit1 or Znhit2 results in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39194072
DOI: 10.1093/biolre/ioae128
PMCID: PMC11565232

Genes

ZNHIT1
ZNHIT2
EFTUD2
NANOG
SOX17
SOX2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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