Article

An Intronic SINE at Pou5f1 Links Hormone Signaling to Blastocyst Hatching

2026-08-26

Abstract excerpt

Before implantation, mammalian embryos must escape from the zona pellucida, a protective glycoprotein coat that surrounds the blastocyst. This process, known as hatching, is essential for uterine attachment and has been viewed largely as a mechanical consequence of blastocyst expansion and zona weakening. Whether hatching is actively timed by embryo-intrinsic gene regulation remains unclear. Here we show that time...

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Literature Corpus work: 49b6314d-5c5f-59cf-aec0-beef0ee2ca8e
DOI: 10.64898/2026.08.25.747035

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