Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The HOXC10/NOD1/ERK axis drives osteolytic bone metastasis of pan-KRAS-mutant lung cancer.

Bone research - 27 Aug 2024

Li Kun, Yang Bo, Du Yingying, Ding Yi, Shen Shihui, Sun Zhengwang, Liu Yun, Wang Yuhan, Cao Siyuan, Ren Wenjie, Wang Xiangyu, Li Mengjuan, Zhang Yunpeng, Wu Juan, Zheng Wei, Yan Wangjun, Li Lei

Abstract excerpt

While KRAS mutation is the leading cause of low survival rates in lung cancer bone metastasis patients, effective treatments are still lacking. Here, we identified homeobox C10 (HOXC10) as a lynchpin in pan-KRAS-mutant lung cancer bone metastasis. Through RNA-seq approach and patient tissue studies, we demonstrated that HOXC10 expression was dramatically increased. Genetic depletion of HOXC10 preferentially...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Neoplasms
Share to Epithelial-Mesenchymal Transition

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Homeodomain Proteins

Share to Lung Neoplasms

Share to MAP Kinase Signaling System

Share to Nod1 Signaling Adaptor Protein

Share to Osteolysis

Share to Proto-Oncogene Proteins p21(ras)

Source

Open in PubMed Open full text

Identifiers

PMID: 39191757
DOI: 10.1038/s41413-024-00350-8
PMCID: PMC11349752

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The HOXC10/NOD1/ERK axis drives osteolytic bone metastasis of pan-KRAS-mutant lung cancer.PMID 39191757Read ↗

The HOXC10/NOD1/ERK axis is sufficient to induce osteolytic bone metastasis of pan-KRAS-mutant lung cancerSemantic proximity Read ↗

Quantitative proteomics identify Tenascin-C as a promoter of lung cancer progression and contributor to a signature prognostic of patient survivalSemantic proximity Read ↗

Live-cell invasive phenotyping uncovers the ALK2/BMP6 iron homeostasis pathway as a therapeutic vulnerability in LKB1-mutant lung cancerSemantic proximity Read ↗

Aberrant activation of wound healing programs within the metastatic niche facilitates lung colonization by osteosarcoma cellsSemantic proximity Read ↗

Pan-cancer exploration of oncogenic and clinical impacts revealed that HOXA9 is a diagnostic indicator of tumorigenesisSemantic proximity Read ↗

Live-Cell Invasive Phenotyping Uncovers ALK2 as a Therapeutic Target in LKB1-Mutant Lung Cancer.Semantic proximity Read ↗

Genome‐wide CRISPR screening identifies the pivotal role of ANKRD42 in colorectal cancer metastasis through EMT regulationSemantic proximity Read ↗

HOXA5 Inhibits Malignant Progression of Lung Adenocarcinoma via Neutrophil Extracellular TrapsSemantic proximity Read ↗

HOXA7 Promotes Metastasis in KRAS Mutant Colorectal Cancer by Regulating Myeloid-derived Suppressor CellsSemantic proximity Read ↗

Epigenetic Modulation and Bone Metastasis: Evolving Therapeutic StrategiesSemantic proximity Read ↗

Identification of cis-HOX-HOXC10 axis as a therapeutic target for colorectal tumor-initiating cells without APC mutations.Semantic proximity Read ↗

The molecular structure and function of sorting nexin 10 in skeletal disorders, cancers, and other pathological conditions.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.