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Article

Identification of cis-HOX-HOXC10 axis as a therapeutic target for colorectal tumor-initiating cells without APC mutations.

Cell reports - 27 Jul 2021

Chen Zhenzhen, Wu Jiayi, Liu Benyu, Zhang Guangtan, Wang Zhiwei, Zhang Lulu, Wang Kaili, Fan Zusen, Zhu Pingping

Abstract excerpt

Colorectal cancer (CRC) is one of the most common cancers worldwide, in which adenomatous polyposis coli (APC) mutations are frequently and uniquely observed. Here we find that cis-HOX (circular RNA stabilizing HOXC10) is robustly expressed in colorectal tumor-initiating cells (TICs). cis-HOX knockout decreases colorectal TIC numbers and impairs the self-renewal, tumorigenesis, and metastatic capacities of TICs,...

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PMID: 34320348
DOI: 10.1016/j.celrep.2021.109431

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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