Quantitative proteomics identify Tenascin-C as a promoter of lung cancer progression and contributor to a signature prognostic of patient survival

Abstract excerpt

Significance Quantitative mass spectrometric profiling of the extracellular matrix composition of normal lung, fibrotic lung, primary lung tumors, and lung metastases to the lymph nodes uncovered specific signatures distinguishing these tissues. CRISPR/Cas9-mediated gene activation of one of the identified factors, Tenascin-C (Tnc), showed that this protein plays a role in mediating lung adenocarcinoma...

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