Article

The HOXC10/NOD1/ERK axis is sufficient to induce osteolytic bone metastasis of pan-KRAS-mutant lung cancer

2023-12-18

Abstract excerpt

<title>Abstract</title> <p>While KRAS mutation is the leading cause of low survival rates in lung cancer bone metastasis patients, effective treatments are still lacking. Here, we identified homeobox C10 (HOXC10) as a lynchpin in pan-KRAS-mutant lung cancer bone metastasis. Through RNA-seq approach and patient tissue studies, we demonstrated that HOXC10 expression was dramatically increased. Genetic depletion of...

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Literature Corpus work: d57d4cea-e0de-53fc-b7b1-a6e45979a02c
DOI: 10.21203/rs.3.rs-3720283/v1

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