Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The molecular structure and function of sorting nexin 10 in skeletal disorders, cancers, and other pathological conditions.

Journal of cellular physiology - 1 Jun 2021

Xu Jiake, Qiu Heng, Zhao Jinmin, Pavlos Nathan J

Abstract excerpt

SNX10 is a member of the phox homology domain-containing family of phosphoinositide-binding proteins. Intracellularly, SNX10 localizes to endosomes where it mediates intracellular trafficking, endosome organization, and protein localization to the centrosome and cilium. It is highly expressed in bone and the gut where it participates in bone mineral and calcium homeostasis through the regulation of osteoclastic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Endosomes
Share to Inflammation
Share to Metabolic Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Osteopetrosis

Share to Protein Conformation

Share to Protein Transport

Share to Sorting Nexins

Share to Structure-Activity Relationship

Source

Identifiers

PMID: 33241559
DOI: 10.1002/jcp.30173

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The molecular structure and function of sorting nexin 10 in skeletal disorders, cancers, and other pathological conditions.PMID 33241559Read ↗

Sorting Nexin 10 as a Key Regulator of Membrane Trafficking in Bone-Resorbing Osteoclasts: Lessons Learned From OsteopetrosisSemantic proximity Read ↗

Osteopetrorickets due to Snx10 deficiency in mice results from both failed osteoclast activity and loss of gastric acid-dependent calcium absorption.Semantic proximity Read ↗

Structure of human SNX10 reveals insights into its role in human autosomal recessive osteopetrosis.Semantic proximity Read ↗

SNX10 gene mutation leading to osteopetrosis with dysfunctional osteoclastsSemantic proximity Read ↗

Genome sequencing identifies a large non-coding region deletion of SNX10 causing autosomal recessive osteopetrosis.Semantic proximity Read ↗

Homozygous stop mutation in the SNX10 gene in a consanguineous Iraqi boy with osteopetrosis and corpus callosum hypoplasia.Semantic proximity Read ↗

SNX10 mutations define a subgroup of human autosomal recessive osteopetrosis with variable clinical severity.Semantic proximity Read ↗

Massive osteopetrosis caused by non-functional osteoclasts in R51Q SNX10 mutant mice.Semantic proximity Read ↗

Sorting Out Sorting Nexins Functions in the Nervous System in Health and DiseaseSemantic proximity Read ↗

The molecular and cellular interplay between the osteopetrosis-associated proteins SNX10, OSTM1, and CLC-7 during osteoclastogenesisSemantic proximity Read ↗

R51Q SNX10 induces osteopetrosis by promoting uncontrolled fusion of monocytes to form giant, non-functional osteoclastsSemantic proximity Read ↗

An SNX10-dependent mechanism downregulates fusion between mature osteoclasts.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.