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Article

Live-Cell Invasive Phenotyping Uncovers ALK2 as a Therapeutic Target in LKB1-Mutant Lung Cancer.

Cancer research - 15 Nov 2024

Koo Junghui, Seong Chang-Soo, Parker Rebecca E, Herrera Amy, Dwivedi Bhakti, Arthur Robert A, Dinasarapu Ashok Reddy, Johnston Henry Richard, Claussen Henry, Tucker-Burden Carol, Ramalingam Suresh S, Fu Haian, Zhou Wei, Marcus Adam I, Gilbert-Ross Melissa

Abstract excerpt

The acquisition of invasive properties is a prerequisite for tumor progression and metastasis. Molecular subtypes of KRAS-driven lung cancer exhibit distinct modes of invasion that contribute to unique growth properties and therapeutic susceptibilities. Despite this, preclinical strategies designed to exploit growth within the context of invasion are lacking. To address this, we designed an experimental system to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39207369
DOI: 10.1158/0008-5472.CAN-23-2631
PMCID: PMC11565166

Genes

BMP6
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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Live-Cell Invasive Phenotyping Uncovers ALK2 as a Therapeutic Target in LKB1-Mutant Lung Cancer.PMID 39207369Read ↗

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