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Article

Effect of protein binding on the pharmacokinetics of the six substrates in the Basel phenotyping cocktail in healthy subjects and patients with liver cirrhosis.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences - 1 Nov 2024

Duthaler Urs, Chapuisat Fabio, Hanimann Robin, Krähenbühl Stephan

Abstract excerpt

Phenotyping serves to estimate enzyme activities in healthy persons and patients in vivo. Low doses of enzyme-specific substrates are administered, and activities estimated using metabolic ratios (MR, calculated as AUCmetabolite/AUCparent). We administered the Basel phenotyping cocktail containing caffeine (CYP1A2 substrate), efavirenz (CYP2B6), flurbiprofen (CYP2C9), omeprazole (CYP2C19), metoprolol (CYP2D6) and...

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PMID: 39182854
DOI: 10.1016/j.ejps.2024.106885

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