Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CombiCap: A novel drug formulation for the basel phenotyping cocktail.

International journal of pharmaceutics - 15 Oct 2016

Camblin Marine, Berger Benjamin, Haschke Manuel, Krähenbühl Stephan, Huwyler Jörg, Puchkov Maxim

Abstract excerpt

Phenotyping of cytochrome P450 isoenzymes is used for metabolic profiling. Phenotyping cocktails are usually administered as individual marketed products, which are not designed for diagnostic applications. Therefore, a formulation strategy was developed, which can be applied to any phenotyping cocktail. The formulation was validated in vitro and in vivo in human volunteers using caffeine, efavirenz,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytochrome P-450 Enzyme System
Share to Drug Combinations

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Healthy Volunteers

Share to Isoenzymes

Share to Pharmaceutical Preparations

Share to Phenotype

Share to Pilot Projects

Source

Identifiers

PMID: 27566010
DOI: 10.1016/j.ijpharm.2016.08.043

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CombiCap: A novel drug formulation for the basel phenotyping cocktail.PMID 27566010Read ↗

Pharmacokinetics and phenotyping properties of the Basel phenotyping cocktail combination capsule in healthy male adults.Semantic proximity Read ↗

The basel cocktail for simultaneous phenotyping of human cytochrome P450 isoforms in plasma, saliva and dried blood spots.Semantic proximity Read ↗

Safety of the Geneva Cocktail, a Cytochrome P450 and P-Glycoprotein Phenotyping Cocktail, in Healthy Volunteers from Three Different Geographic Origins.Semantic proximity Read ↗

Cocktail approach for in vivo phenotyping of 5 major CYP450 isoenzymes: development of an effective sampling, extraction, and analytical procedure and pilot study with comparative genotyping.Semantic proximity Read ↗

Evaluation of Mutual Drug-Drug Interaction within Geneva Cocktail for Cytochrome P450 Phenotyping using Innovative Dried Blood Sampling Method.Semantic proximity Read ↗

Effects of Cytochrome P450 Inhibition and Induction on the Phenotyping Metrics of the Basel Cocktail: A Randomized Crossover Study.Semantic proximity Read ↗

An improved cytochrome P450 phenotyping cocktail with a simplified and highly sensitive UHPLC-MS/MS assay in human plasma.Semantic proximity Read ↗

Geneva cocktail for cytochrome p450 and P-glycoprotein activity assessment using dried blood spots.Semantic proximity Read ↗

Simultaneous Determination of Cytochrome P450 Oxidation Capacity in Humans: A Review on the Phenotyping Cocktail Approach.Semantic proximity Read ↗

A simplified analytical method for a phenotyping cocktail of major CYP450 biotransformation routes.Semantic proximity Read ↗

In vivo Phenotyping Methods: Cytochrome P450 Probes with Emphasis on the Cocktail Approach.Semantic proximity Read ↗

Multiplex Phenotyping for Systems Medicine: A One-Point Optimized Practical Sampling Strategy for Simultaneous Estimation of CYP1A2, CYP2C9, CYP2C19, and CYP2D6 Activities Using a Cocktail Approach.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.