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Epigenetic and genetic risk of Alzheimer disease from autopsied brains in two ethnic groups.

Acta neuropathologica - 23 Aug 2024

Ma Yiyi, Reyes-Dumeyer Dolly, Piriz Angel, Recio Patricia, Mejia Diones Rivera, Medrano Martin, Lantigua Rafael A, Vonsattel Jean Paul G, Tosto Giuseppe, Teich Andrew F, Ciener Benjamin, Leskinen Sandra, Sivakumar Sharanya, DeTure Michael, Ranjan Duara, Dickson Dennis, Murray Melissa, Lee Edward, Wolk David A, Jin Lee-Way, Dugger Brittany N, Hiniker Annie, Rissman Robert A, Mayeux Richard, Vardarajan Badri N

Abstract excerpt

Genetic variants and epigenetic features both contribute to the risk of Alzheimer's disease (AD). We studied the AD association of CpG-related single nucleotide polymorphisms (CGS), which act as a hub of both the genetic and epigenetic effects, in Caribbean Hispanics (CH) and generalized the findings to Non-Hispanic Whites (NHW). First, we conducted a genome-wide, sliding-window-based association with AD, in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39177846
DOI: 10.1007/s00401-024-02778-y
PMCID: PMC11343944

Genes

APOE
TOMM40
ADAM20
SPG7
SYNDIG1L
VRTN
SYNDIG1

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